In vitro antidiabetic, aphrodisiac and antimicrobial properties of para-propoxybenzoic acid isolated from Acacia auriculiformis A. Cunn Ex. Benth (Fabaceae) stem bark


 Purpose: To investigate the in vitro antidiabetic, aphrodisiac and antimicrobial properties of para-propoxybenzoic acid isolated from Acacia auriculiformis stem bark.
 Methods: Powdered dried bark A. was extracted with 70 % ethanol water extract obtained suspended partitioned ethyl acetate n-butanol to give their respective soluble fractions. The fraction being more active, terms in-vitro aphrodisiac, antidiabetic properties, subjected chromatographic separation obtain C1 identified as parapropoxybenzoic acid, which also evaluated for using standard procedures.
 Results: 4-Propoxybenzoic showed a weak property not significantly different (p < 0.05) that control (normal saline) all sexual parameters tested. compound exhibited activity by dose-dependently inhibiting actions α-amylase half-maximal concentration (IC50) value 50 ± 0.45 μg/mL. In this regard, it comparable standard, acarbose (30 0.18 μg/mL). study, 200 μg/mL gave highest zone inhibition 18 0.23 mm against Vibo cholriae (NCTC 5438)
 Conclusion: results indicate compound, 4-propoxybenzoic, exhibits good anti-microbial but properties.